New gene functions in megakaryopoiesis and platelet formation
C Gieger, A Radhakrishnan, A Cvejic, W Tang, E Porcu… - Nature, 2011 - nature.com
Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological
ranges, but there is only limited understanding of the molecular processes controlling both
traits. Here we carried out a high-powered meta-analysis of genome-wide association
studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive
biological and functional assessment. We identified 68 genomic loci reliably associated with …
haemostasis. Their count and volume are tightly controlled within narrow physiological
ranges, but there is only limited understanding of the molecular processes controlling both
traits. Here we carried out a high-powered meta-analysis of genome-wide association
studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive
biological and functional assessment. We identified 68 genomic loci reliably associated with …
[引用][C] New gene functions in megakaryopoiesis and platelet formation
C Meisinger, C Gieger, N Soranzo… - 2011 - opus.bibliothek.uni-augsburg.de
OPUS 4 | New gene functions in megakaryopoiesis and platelet formation … New gene
functions in megakaryopoiesis and platelet formation …
functions in megakaryopoiesis and platelet formation …
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