As an extension to our previous work for the development of new thalidomide analogs, the
current work offers new insights into the immunomodulatory and anticancer activities of
quinazolinone based molecules carrying a glutarimide moiety. The findings confirmed some
previous findings and revealed some new information. Among the newly synthesized
compounds, compounds 7d and 12 showed considerable immunomodulatory properties in
comparison to thalidomide. 7d and 12 significantly reduced TNF-α levels in HepG-2 cells …

Aim: The current work is an extension to our previous work for the development of new
thalidomide analogs. Materials & methods: Quinazolinone-based molecules carrying a
glutarimide moiety have been designed, synthesized and biologically evaluated for
immunomodulatory and anticancer activity. Results: Compounds 7d and 12 showed
considerable immunomodulatory properties in comparison to thalidomide. 7d and 12
significantly reduced TNF-α levels in HepG-2 cells from 162.5 to 57.4 pg/ml and 49.2 pg/ml …