New potential antitumor pyrazole derivatives: Synthesis and cytotoxic evaluation

GM Nitulescu, C Draghici, OT Olaru - International journal of molecular …, 2013 - mdpi.com
potential of the aminopyrazoles, we prepared a series of new pyrazole derivatives and
evaluated their toxicological profile using Artemia salina, Daphnia magna and their cytotoxic

Synthesis of novel 1, 3, 4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents

AH Abadi, AAH Eissa, GS Hassan - Chemical and pharmaceutical …, 2003 - jstage.jst.go.jp
… Furthermore, the pyrazole derivative celecoxib 2 and SC236 3, have been found to exhibit
potential antimigratory activity, inhibit neovascularization, decrease VEGF production and …

Synthesis, structural characterization and anticancer evaluation of pyrazole derivatives

MSA El-Gaby, MM Ghorab, ZH Ismail… - Medicinal Chemistry …, 2018 - Springer
new pyrazole derivatives have demonstrated promising anti proliferative and cytotoxic … It
is clear from the present data that the comparison of the cytotoxicity of the pyrazole derivatives

Synthesis and evaluation of new pyrazoline derivatives as potential anticancer agents

M Karabacak, MD Altıntop, Hİ Çiftçi, R Koga, M Otsuka… - Molecules, 2015 - mdpi.com
… In the present paper, new pyrazoline derivatives were synthesized and investigated for
their antiproliferative effects on AsPC-1 human pancreatic adenocarcinoma, U87, and U251 …

Synthesis of new pyrazole derivatives and their anticancer evaluation

GM Nitulescu, C Draghici, AV Missir - European journal of medicinal …, 2010 - Elsevier
… Based on the model of these aforementioned pyrazole urea derivatives, 1-… synthesized
some chimeric thiourea-pyrazole derivatives. Fig. 1 shows relevant antitumor pyrazole derivatives

Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

FE Bennani, L Doudach, Y Cherrah, Y Ramli… - Bioorganic …, 2020 - Elsevier
… As already mentioned above, the pyrazoles and their derivatives possess several … anticancer
activity of pyrazole derivatives, since several authors have synthesized a novel anti-tumor

Design, synthesis, and evaluation of some novel heterocycles bearing pyrazole moiety as potential anticancer agents

N Abdelgawad, MF Ismail, MH Hekal… - Journal of …, 2019 - Wiley Online Library
… In this study, reaction of chalconated pyrazole derivative 1 with diethyl malonate under two
different reaction conditions was also investigated as shown in Scheme 2. Therefore, reaction …

Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents

SM Gomha, TA Salah, AO Abdelhamid - Monatshefte für Chemie …, 2015 - Springer
… that many derivatives of thiazole and 1,3,4-thiadiazole have antitumor activity … synthesis
of a new series of substituted thiadiazoles and thiazoles for the examination of their antitumor

New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies

IMM Othman, ZM Alamshany, NY Tashkandi… - Bioorganic …, 2021 - Elsevier
… , new pyrimidine-2-one(thione) and pyrazole derivatives … designed, synthesized and
evaluated as cytotoxic candidates … All the new compounds revealed more potent cytotoxic activity …

Novel pyrazole derivatives as anticancer and radiosensitizing agents

HM Aly, MG El-Gazzar - Arzneimittelforschung, 2012 - thieme-connect.com
… were synthesized and tested over the years, the use of this … several pyrazole derivatives
proved to have potent anticancer … , a series of pyrazole derivatives containing an urea scaffold …