Nitric oxide synthesis and action in an invertebrate brain
MR Elphick, IC Green, M O'Shea - Brain research, 1993 - Elsevier
MR Elphick, IC Green, M O'Shea
Brain research, 1993•ElsevierNitric oxide (NO) is synthesized in mammalian neurons by Ca 2+/calmodulin activated NO
synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in
target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase
are present in the brain of the locustSchistocerca gregaria. Our observations indicate, for the
first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.
synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in
target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase
are present in the brain of the locustSchistocerca gregaria. Our observations indicate, for the
first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.
Abstract
Nitric oxide (NO) is synthesized in mammalian neurons by Ca2+/calmodulin activated NO synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase are present in the brain of the locustSchistocerca gregaria. Our observations indicate, for the first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.
Elsevier
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