Nociceptive, emotional, electrophysiological, and histological characterization of the chronic constriction injury model in female Wistar Han rats
D Fonseca-Rodrigues, I Laranjeira, J Barbosa… - Brain Research …, 2021 - Elsevier
Abstract Chronic neuropathic pain affects 7–10% of the population and is often
accompanied by comorbid emotional disorders, which greatly reduce the quality of life of the
patients, impairing physical, cognitive, emotional, and social functioning. Despite the higher
prevalence and severity of chronic pain in women, the number of publications using female
animals remains scarce. While in the chronic constriction injury (CCI) model the
development of mechanical/thermal hyperalgesia, allodynia and spontaneous pain has …
accompanied by comorbid emotional disorders, which greatly reduce the quality of life of the
patients, impairing physical, cognitive, emotional, and social functioning. Despite the higher
prevalence and severity of chronic pain in women, the number of publications using female
animals remains scarce. While in the chronic constriction injury (CCI) model the
development of mechanical/thermal hyperalgesia, allodynia and spontaneous pain has …
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