Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute …
The correlates of natural protective immunity to SARS-CoV-2 in the majority who experience
asymptomatic infection or non-severe disease are not fully characterised, and remain
important as new variants emerge. We addressed this question using blood transcriptomics,
multiparameter flow cytometry and T cell receptor (TCR) sequencing spanning the time of
incident infection. We identified a type 1 interferon (IFN) response common to other acute
respiratory viruses, and a cell proliferation response that discriminated SARS-CoV-2 from …
asymptomatic infection or non-severe disease are not fully characterised, and remain
important as new variants emerge. We addressed this question using blood transcriptomics,
multiparameter flow cytometry and T cell receptor (TCR) sequencing spanning the time of
incident infection. We identified a type 1 interferon (IFN) response common to other acute
respiratory viruses, and a cell proliferation response that discriminated SARS-CoV-2 from …
[PDF][PDF] Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type
A Chandran, J Rosenheim, G Nageswaran… - hospital, 2020 - scholar.archive.org
The correlates of natural protective immunity to SARS-CoV-2 in the majority who experience
asymptomatic infection or non-severe disease are not fully characterised, and remain
important as new variants emerge. We addressed this question using blood transcriptomics,
multiparameter flow cytometry and T cell receptor (TCR) sequencing spanning the time of
incident infection. We identified a type 1 interferon (IFN) response common to other acute
respiratory viruses, and a cell proliferation response that discriminated SARS-CoV-2 from …
asymptomatic infection or non-severe disease are not fully characterised, and remain
important as new variants emerge. We addressed this question using blood transcriptomics,
multiparameter flow cytometry and T cell receptor (TCR) sequencing spanning the time of
incident infection. We identified a type 1 interferon (IFN) response common to other acute
respiratory viruses, and a cell proliferation response that discriminated SARS-CoV-2 from …
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