Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an
encapsulated or clearly delimited, noninvasive neoplasm with a follicular growth pattern and
nuclear features of papillary thyroid carcinoma (PTC). It is considered a 'pre-malignant'lesion
of the RAS-like group. Ultrasonography (US), cytology and molecular tests are useful to
suspect thyroid nodules that correspond to NIFTP but there is wide overlap of the results with
the encapsulated follicular variant of PTC (E-FVPTC). In these nodules that possibly or likely …

The rising incidence of papillary thyroid carcinoma is linked in part to inclusion of
noninvasive follicular variant of papillary thyroid carcinoma. Despite its designation as
carcinoma, noninvasive follicular variant of papillary thyroid carcinoma appears to be
exceptionally indolent, often over treated by current treatment practices. Additionally, criteria
for diagnosis have historically been subjective and challenging. Recently, an international
multidisciplinary collaborative group performed a clinicopathologic survey of such cases …