Norsquaraine endowed with anticancer and antibacterial activities

A Toksoy, Ö Sonkaya, DS Erkan, RB Gulen… - Photodiagnosis and …, 2022 - Elsevier
Background Photodynamic therapy (PDT) is a method for the treatment of cancer.
Furthermore, PDT can also be used for the eradication of bacteria. The photo-sensitizing
drug, aka photosensitizer, is critical for the success of PDT. Although norsquaraines are
analogs of squaraine dyes, they are overlooked as photosensitizers. Methods In this work,
synthesis, characterization, bioimaging and in vitro PDT applications of a new norsquaraine
dye 1 were described. We also prepared nanoparticles from norsquaraine 1 and Pluronic …

Norsquaraine endowed with anticancer and antibacterial activities

R Boran Gülen, Ö Sonkaya, DS Erkan, A Toksoy… - 2022 - acikerisim.aksaray.edu.tr
Photodynamic therapy (PDT) is a method for the treatment of cancer. Furthermore, PDT can
also be used for the eradication of bacteria. The photo-sensitizing drug, aka photosensitizer,
is critical for the success of PDT. Although norsquaraines are analogs of squaraine dyes,
they are overlooked as photosensitizers. Methods: In this work, synthesis, characterization,
bioimaging and in vitro PDT applications of a new norsquaraine dye 1 were described. We
also prepared nanoparticles from norsquaraine 1 and Pluronic F127 to obtain 1@ F127 …
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