The colon is a site where both local and systemic delivery of drugs can take place. Local
delivery allows topical treatment of inflammatory bowel disease. However, treatment can be
made effective if the drugs can be targeted directly into the colon, thereby reducing the
systemic side effects. This review, mainly compares the primary approaches for CDDS
(Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and
microbially triggered systems, which achieved limited success and had limitations as …