Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including
heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss.
Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling
and cleaning process, declines with age across a large spectrum of model organisms and is
thought to be responsible for a subset of age-induced changes. Here, we show that a 6-
month administration of the natural autophagy inducer spermidine in the drinking water to …