Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie
P Papasavva-Stylianou, M Kleanthous… - The Veterinary …, 2007 - Elsevier
To discern whether an association exists between specific combinations of polymorphisms
of the prion protein (PrP) and natural scrapie in Cyprus goats, 250 goats were examined,
including 164 histologically positive cases. Previously reported amino acid polymorphisms
were detected at codons 154 (R→ H), 168 (P→ Q), 220 (Q→ H) and 240 (S→ P) and
nucleotide alterations at codons 42 (a→ g) and 138 (c→ t). Additionally, novel amino acid
polymorphisms were detected at codons 146 (N→ S or D) and 151 (R→ H) and new “silent” …
of the prion protein (PrP) and natural scrapie in Cyprus goats, 250 goats were examined,
including 164 histologically positive cases. Previously reported amino acid polymorphisms
were detected at codons 154 (R→ H), 168 (P→ Q), 220 (Q→ H) and 240 (S→ P) and
nucleotide alterations at codons 42 (a→ g) and 138 (c→ t). Additionally, novel amino acid
polymorphisms were detected at codons 146 (N→ S or D) and 151 (R→ H) and new “silent” …
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