[HTML][HTML] Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal
functions. However, the possible extragonadal effects of AMH on the hypothalamic–pituitary–
gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH
neurons both in mice and humans express the AMH receptor, and that AMH potently
activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we
show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a …
functions. However, the possible extragonadal effects of AMH on the hypothalamic–pituitary–
gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH
neurons both in mice and humans express the AMH receptor, and that AMH potently
activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we
show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a …