Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism
Z Talebizadeh, DY Lam, MF Theodoro… - Journal of medical …, 2006 - jmg.bmj.com
Objective: To screen cDNA for NLGN3 and NLGN4 from lymphoblastoid cells from autistic
subjects. Methods and results: 10 young autistic females and 30 non-autistic subjects were
studied for alterations in two X linked genes, NLGN3 and NLGN4. A novel NLGN4 isoform
lacking exon 4, which occurred de novo on the paternal allele, was identified in one of the
autistic females. Monoallelic expression of NLGN4 was seen in this subject and in 11 of 14
informative autistic and non-autistic females using a single nucleotide polymorphism found …
subjects. Methods and results: 10 young autistic females and 30 non-autistic subjects were
studied for alterations in two X linked genes, NLGN3 and NLGN4. A novel NLGN4 isoform
lacking exon 4, which occurred de novo on the paternal allele, was identified in one of the
autistic females. Monoallelic expression of NLGN4 was seen in this subject and in 11 of 14
informative autistic and non-autistic females using a single nucleotide polymorphism found …
[引用][C] Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism
以上显示的是最相近的搜索结果。 查看全部搜索结果