Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass
analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the
treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated
the drug-likeness properties of the titled compounds with developmental challenges in
lipophilicity and solubility parameters. The in vitro assessment of the synthesized …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass
analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the
treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated
the drug-likeness properties of the titled compounds with developmental challenges in
lipophilicity and solubility parameters. The in vitro assessment of the synthesized …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
S Murugesan - 2022 - dspace.bits-pilani.ac.in
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass
analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the
treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated
the drug-likeness properties of the titled compounds with developmental challenges in
lipophilicity and solubility parameters. The in vitro assessment of the synthesized …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass
analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the
treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated
the drug-likeness properties of the titled compounds with developmental challenges in
lipophilicity and solubility parameters. The in vitro assessment of the synthesized …
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