Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
NF-E2-related factor 2 (Nrf2) is the key transcription factor regulating the antioxidant
response. Previous studies identified a nuclear localization signal (NLS) in the basic region
and a nuclear exporting signal (NES) in the leucine zipper domain of Nrf2. In this study, we
characterize a new functional NES (175 LLSIPELQCLNI 186) in the transactivation (TA)
domain of Nrf2. A green fluorescence protein (GFP)-tagged Nrf2 segment (amino acids162-
295) called GFP-NES TA exhibited a cytosolic distribution that could be disrupted by L184A …
response. Previous studies identified a nuclear localization signal (NLS) in the basic region
and a nuclear exporting signal (NES) in the leucine zipper domain of Nrf2. In this study, we
characterize a new functional NES (175 LLSIPELQCLNI 186) in the transactivation (TA)
domain of Nrf2. A green fluorescence protein (GFP)-tagged Nrf2 segment (amino acids162-
295) called GFP-NES TA exhibited a cytosolic distribution that could be disrupted by L184A …
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