[HTML][HTML] ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma
C Dubois, K Kondratska, A Kondratskyi… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract Changes in cytosolic free Ca 2+ concentration play a central role in many
fundamental cellular processes including muscle contraction, neurotransmission, cell
proliferation, differentiation, gene transcription and cell death. Many of these processes are
known to be regulated by store-operated calcium channels (SOCs), among which ORAI1 is
the most studied in cancer cells, leaving the role of other ORAI channels yet inadequately
addressed. Here we demonstrate that ORAI3 channels are expressed in both normal …
fundamental cellular processes including muscle contraction, neurotransmission, cell
proliferation, differentiation, gene transcription and cell death. Many of these processes are
known to be regulated by store-operated calcium channels (SOCs), among which ORAI1 is
the most studied in cancer cells, leaving the role of other ORAI channels yet inadequately
addressed. Here we demonstrate that ORAI3 channels are expressed in both normal …
ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma.
N Ziental Gelus, F Vanden Abeele, C Dubois… - 2021 - lilloa.univ-lille.fr
Changes in cytosolic free Ca2+ concentration play a central role in many fundamental
cellular processes including muscle contraction, neurotransmission, cell proliferation,
differentiation, gene transcription and cell death. Many of these processes are known to be
regulated by store-operated calcium channels (SOCs), among which ORAI1 is the most
studied in cancer cells, leaving the role of other ORAI channels yet inadequately addressed.
Here we demonstrate that ORAI3 channels are expressed in both normal (HPDE) and …
cellular processes including muscle contraction, neurotransmission, cell proliferation,
differentiation, gene transcription and cell death. Many of these processes are known to be
regulated by store-operated calcium channels (SOCs), among which ORAI1 is the most
studied in cancer cells, leaving the role of other ORAI channels yet inadequately addressed.
Here we demonstrate that ORAI3 channels are expressed in both normal (HPDE) and …
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