The prevalence of obesity is increasing in the world, and obesity-induced disease, insulin-
resistance, cardiovascular disease, and malignancies are becoming a problem.
Epidemiological studies have shown that obesity is associated with advanced prostate
cancer and that obese men with prostate cancer have a poorer prognosis. Obesity induces
systemic inflammation via several mechanisms. High-fat diet-induced prostate cancer
progresses via adipose-secretory cytokines or chemokines. Inflammatory cells play …

Obesity and the associated metabolic syndrome produce a complex set of alterations both
systemically and locally in tissues that support cancer development and progression. In
prostate cancer (PCa), the weight of evidence suggests that obesity is primarily associated
with more aggressive disease and increased risk of biochemical failure following
prostatectomy or radiation treatment. Inflammation processes and inflammation-associated
signaling pathways are upregulated in the obese state, and both human and mouse studies …