Oligomeric α-synuclein is increased in basal tears of Parkinson's patients
SF Hamm-Alvarez, CT Okamoto, SR Janga… - Biomarkers in …, 2019 - Taylor & Francis
Biomarkers in medicine, 2019•Taylor & Francis
Aim: Secretion of proteins into basal tears of Parkinson's disease (PD) patients may be
altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total
α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears from 93 PD patients
and 82 age-and sex-equivalent healthy controls. Results: α-SynTotal was decreased (p=
0.0043), whereas α-SynOligo (p< 0.0001) and the ratio of α-SynOligo/α-SynTotal (p<
0.0001) were increased in basal tears from PD patients compared with healthy controls …
altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total
α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears from 93 PD patients
and 82 age-and sex-equivalent healthy controls. Results: α-SynTotal was decreased (p=
0.0043), whereas α-SynOligo (p< 0.0001) and the ratio of α-SynOligo/α-SynTotal (p<
0.0001) were increased in basal tears from PD patients compared with healthy controls …
Aim
Secretion of proteins into basal tears of Parkinson’s disease (PD) patients may be altered by changes in nerve function. Materials & methods
Oligomeric α-SynOligo and total α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears from 93 PD patients and 82 age- and sex-equivalent healthy controls. Results
α-SynTotal was decreased (p = 0.0043), whereas α-SynOligo (p < 0.0001) and the ratio of α-SynOligo/α-SynTotal (p < 0.0001) were increased in basal tears from PD patients compared with healthy controls. Area under receiver-operating curves of α-SynOligo and α-SynOligo/α-SynTotal contents were 0.70 (95% confidence limits: 0.621–0.774) and 0.72 (95% confidence limits: 0.642–0.792). Conclusion
PD patient basal tears may contain biomarkers that can be assayed noninvasively and inexpensively.
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