This paper contributes to the characterization of a certain class of commutative Hopf algebroids. It is shown that a commutative flat Hopf algebroid with a non zero base ring and a nonempty character groupoid is geometrically transitive if and only if any base change morphism is a weak equivalence (in particular, if any extension of the base ring is Landweber exact), if and only if any trivial bundle is a principal bi-bundle, and if and only if any two objects are fpqc locally isomorphic. As a consequence, any two isotropy Hopf algebras of a geometrically transitive Hopf algebroid (as above) are weakly equivalent. Furthermore, the character groupoid is transitive and any two isotropy Hopf algebras are conjugated. Several other characterizations of these Hopf algebroids in relation to transitive groupoids are also given.