[PDF][PDF] Optic nerve disturbances: a new form of paclitaxel neurotoxicity
G Capri, E Munzone, E Tarenzi, F Fulfaro… - Journal of the National …, 1994 - air.unimi.it
The neurotoxicity of paclitaxel (Taxol) is cumulative and primarily characterized by a sensory
and motor peripheral neuropathy (1-3). We describe here visual disturbances and
neurologic findings consistent with a toxicity of paclitaxel to the optic nerve. The symptoms
occurred in relapsed breast cancer patients during an ongoing trial of paclitaxel
administered every 3 weeks by 3-hour infusion at the dose of 175 mg/m2 (15 patients) or
225 mg/m2 (32 patients)(4). The trial was approved by the local ethics committee, and all …
and motor peripheral neuropathy (1-3). We describe here visual disturbances and
neurologic findings consistent with a toxicity of paclitaxel to the optic nerve. The symptoms
occurred in relapsed breast cancer patients during an ongoing trial of paclitaxel
administered every 3 weeks by 3-hour infusion at the dose of 175 mg/m2 (15 patients) or
225 mg/m2 (32 patients)(4). The trial was approved by the local ethics committee, and all …
Optic Nerve Disturbances: a New Form of Paclitaxel Neurotoxicity
P SOULIE, E CVITKOVIC - Clin Oncol, 1989 - academic.oup.com
Abstract “Application of Pharmacokinetically Guided Dose Escalation With Respect to Cell
Cycle Phase Specificity,” by E. Fuse, S. Kobayashi, M. Inaba, et al.[J Natl Cancer Inst 86: 989-
996, 1994 (Issue 13)]. Because of a printer's error, information was omitted from three of the
figures: logSS/N= 0.149 [Fig. 1]; logSS/N= 1.629 [Fig. 2]; logSS/N [above the numbers 0.190
and 0.078 in Fig. 3]. The Journal regrets the error.
Cycle Phase Specificity,” by E. Fuse, S. Kobayashi, M. Inaba, et al.[J Natl Cancer Inst 86: 989-
996, 1994 (Issue 13)]. Because of a printer's error, information was omitted from three of the
figures: logSS/N= 0.149 [Fig. 1]; logSS/N= 1.629 [Fig. 2]; logSS/N [above the numbers 0.190
and 0.078 in Fig. 3]. The Journal regrets the error.
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