The term microgrid refers to small-scale power grid that can operate autonomously or in concurrence with the area’s main electrical grid. The intermittent characteristic of DGs which defies the power quality and voltage manifests the requirement for new planning and operation approaches for microgrids. Consequently, conventional optimization methods in new power systems have been critically biased all through the previous decade. One of the main technological and inexpensive tools in this regard is the optimal generation scheduling of microgrid. As a primary optimization tool in the planning and operation fields, optimal operation has an undeniable part in the power system. This paper reviews and evaluates the optimal operation approaches mostly related to microgrids. In this work, the foremost optimal generation scheduling approaches are compared in terms of their objective functions, techniques and constraints. To conclude, a few fundamental challenges occurring from the latest optimal generation scheduling techniques in microgrids are addressed.