Optimization of cardiac cine in the rat on a clinical 1.5-T MR system
K Montet-Abou, JL Daire, MK Ivancevic… - … Resonance Materials in …, 2006 - Springer
K Montet-Abou, JL Daire, MK Ivancevic, JN Hyacinthe, D Nguyen, M Jorge-Costa, DR Morel…
Magnetic Resonance Materials in Physics, Biology and Medicine, 2006•SpringerObject: the overall goal was to study cardiovascular function in small animals using a clinical
1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and
temporal resolution. Materials and methods: normal rat hearts (n= 9) were imaged using a
1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners)
sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners)
sequences with different in-plane resolution, and with and without flow compensation and …
1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and
temporal resolution. Materials and methods: normal rat hearts (n= 9) were imaged using a
1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners)
sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners)
sequences with different in-plane resolution, and with and without flow compensation and …
Abstract
Object: the overall goal was to study cardiovascular function in small animals using a clinical 1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and temporal resolution.
Materials and methods: normal rat hearts (n = 9) were imaged using a 1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners) sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners) sequences with different in-plane resolution, and with and without flow compensation and half-Fourier acquisition. The hearts of four rats were then excised and left-ventricle mass was weighed. Inter- and intra-observer variability analysis was performed for magnetic resonance imaging (MRI) measurements.
Results: half-Fourier acquisition with flow compensation gave the best sequence in terms of image quality, spatial as well as temporal resolution, and suppression of flow artifact. Ejection fraction was 71 ± 4% with less than 5% inter- and intra-observer variability. A good correlation was found between MRI-calculated left-ventricular mass and wet weight.
Conclusions: using optimized sequences on a clinical 1.5-T MR scanner can provide accurate quantification of cardiac function in small animals and can promote cardiovascular research on small animals at 1.5-T
Springer
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