Organ-specific microcirculatory mass transport of oxycodone in humans: clinical implications for therapeutic use
Objectives: To begin to address the problem of heterogeneity of distribution of oxycodone
(OC) in humans, we developed an organ-specific microcirculatory capillary-tissue exchange
2-compartment model for studying regional OC mass transport. Materials and Methods: The
model was developed in silico. It quantifies OC's organ-specific mass transport rates,
clearances and recycling, and it considers the effects of blood flow on OC's convective and
diffusive transport. Results: What is new is the finding that OC undergoes local recycling at …
(OC) in humans, we developed an organ-specific microcirculatory capillary-tissue exchange
2-compartment model for studying regional OC mass transport. Materials and Methods: The
model was developed in silico. It quantifies OC's organ-specific mass transport rates,
clearances and recycling, and it considers the effects of blood flow on OC's convective and
diffusive transport. Results: What is new is the finding that OC undergoes local recycling at …
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