An investigation was carried out to study the effect of organic and inorganic fertilizer on growth, yield and quality of tomato (Solanum lycopersicum L.) hybrid cv.(GS-600) under protected cultivation at research station, Department of Horticulture, Sam Higginbottom University of Agriculture, Technology and Science, Allahabad, India, during 2013-14. Ten treatments were tested in randomized block design with three replications where treatment T7 (50% RDF+ 25% FYM+ 25% VC) showed significant and best results in term of maximum plant height (259.13 cm), more number of flowers per cluster (7.40) and number of clusters per plant (9.80), highest fruits set percentage (97.33), highest number of fruits per cluster (7.63), and similarly showed significant contribution in yield related traits ie maximum number of fruits per plant (113.33), maximum average fruit weight (196.67 g), highest fruit yield per plant (22.28 kg), highest fruit yield per plot (222.70 kg), higher yield per 151.87 m2 (2236.57 kg), and also in quality parameters ie maximum juice percent (95.57), maximum specific gravity (0.97 g), maximum vitamin C (19.73 mg/100g of fruit juice) and maximum TSS (4.00 B). Due to the better yield and quality results in treatment T7 (50% RDF+ 25% FYM+ 25% VC), the economic analysis proved it as a best treatment in term of maximum net return (24390.29) and Benefit cost ratio (2.19), as followed by T9 and T8which were superior over the control. Therefore, these treatments may be recommended to exploit the better eco-friendly economic yield of tomato. It will ensure the sustainability in production and soil health.