Organocatalytic Activation of Donor–Acceptor Cyclopropanes: A Tandem (3+ 3)-Cycloaddition/Aryl Migration toward the Synthesis of Enantioenriched …
An organocatalytic enantioselective (3+ 3)-cycloaddition reaction of racemic cyclopropane
carbaldehydes and aryl hydrazones has been demonstrated for the first time. A wide range
of enantioenriched tetrahydropyridazines with an exocyclic double bond were obtained with
moderate to good yields and good to excellent enantiomeric excesses. Mechanistic
investigations hinted toward a matched/mismatched kinetic resolution, and control
experiments and DFT calculations unveiled that 1, 3-aryl migration was concerted and …
carbaldehydes and aryl hydrazones has been demonstrated for the first time. A wide range
of enantioenriched tetrahydropyridazines with an exocyclic double bond were obtained with
moderate to good yields and good to excellent enantiomeric excesses. Mechanistic
investigations hinted toward a matched/mismatched kinetic resolution, and control
experiments and DFT calculations unveiled that 1, 3-aryl migration was concerted and …
Organocatalytic Activation of Donor–Acceptor Cyclopropanes: A Tandem (3+ 3)-Cycloaddition/Aryl Migration toward the Synthesis of Enantioenriched …
An organocatalytic enantioselective (3+ 3)-cycloaddition reaction of racemic cyclopropane
carbaldehydes and aryl hydrazones has been demonstrated for the first time. A wide range
of enantioenriched tetrahydropyridazines with an exocyclic double bond were obtained with
moderate to good yields and good to excellent enantiomeric excesses. Mechanistic
investigations hinted toward a matched/mismatched kinetic resolution, and control
experiments and DFT calculations unveiled that 1, 3-aryl migration was concerted and …
carbaldehydes and aryl hydrazones has been demonstrated for the first time. A wide range
of enantioenriched tetrahydropyridazines with an exocyclic double bond were obtained with
moderate to good yields and good to excellent enantiomeric excesses. Mechanistic
investigations hinted toward a matched/mismatched kinetic resolution, and control
experiments and DFT calculations unveiled that 1, 3-aryl migration was concerted and …
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