Bisphosphonates have a profound effect on bone resorption and are widely used in the
treatment of osteoclast-mediated bone diseases. Zoledronic acid (ZA), a third-generation
biphosphonate, has a potent antitumor activity and expands gammadelta (γδ) T cells
endowed of major histocompatibility complex-unrestricted lytic activity. Many solid tumors
express tumor-specific antigens on their surface, representing targets for immune effector T
cells. Nevertheless, the immune surveillance against clinically manifested tumors is …