Osthole stimulates osteoblast differentiation and bone formation by activation of β‐catenin–BMP signaling

DZ Tang, W Hou, Q Zhou, M Zhang… - Journal of Bone and …, 2010 - academic.oup.com
Osteoporosis is defined as reduced bone mineral density with a high risk of fragile fracture.
Current available treatment regimens include antiresorptive drugs such as estrogen receptor
analogues and bisphosphates and anabolic agents such as parathyroid hormone (PTH).
However, neither option is completely satisfactory because of adverse effects. It is thus
highly desirable to identify novel anabolic agents to improve future osteoporosis treatment.
Osthole, a coumarin‐like derivative extracted from Chinese herbs, has been shown to …

Osthole stimulates osteoblast differentiation and bone formation by activation of β-catenin-BMP signaling.

TDZ Tang DeZhi, HW Hou Wei, ZQ Zhou Quan… - 2010 - cabidigitallibrary.org
Osteoporosis is defined as reduced bone mineral density with a high risk of fragile fracture.
Current available treatment regimens include antiresorptive drugs such as estrogen receptor
analogues and bisphosphates and anabolic agents such as parathyroid hormone (PTH).
However, neither option is completely satisfactory because of adverse effects. It is thus
highly desirable to identify novel anabolic agents to improve future osteoporosis treatment.
Osthole, a coumarin-like derivative extracted from Chinese herbs, has been shown to …
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