[HTML][HTML] Overlapping binding sites of the frataxin homologue assembly factor and the heat shock protein 70 transfer factor on the Isu iron-sulfur cluster scaffold protein
M Manicki, J Majewska, S Ciesielski, B Schilke… - Journal of Biological …, 2014 - ASBMB
In mitochondria FeS clusters, prosthetic groups critical for the activity of many proteins, are
first assembled on Isu, a 14-kDa scaffold protein, and then transferred to recipient
apoproteins. The assembly process involves interaction of Isu with both Nfs1, the cysteine
desulfurase serving as a sulfur donor, and the yeast frataxin homolog (Yfh1) serving as a
regulator of desulfurase activity and/or iron donor. Here, based on the results of biochemical
experiments with purified wild-type and variant proteins, we report that interaction of Yfh1 …
first assembled on Isu, a 14-kDa scaffold protein, and then transferred to recipient
apoproteins. The assembly process involves interaction of Isu with both Nfs1, the cysteine
desulfurase serving as a sulfur donor, and the yeast frataxin homolog (Yfh1) serving as a
regulator of desulfurase activity and/or iron donor. Here, based on the results of biochemical
experiments with purified wild-type and variant proteins, we report that interaction of Yfh1 …
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