Methods: In vitro release studies were performed to optimise an actuation regime for controlled release of the model drug, Fluorescein isothiocyanate–Diethylaminoethyl–Dextran (Dextran)(same charge and molecular weight as VEGF), from a hydrogel loaded SRDD device. The SRDD device was submerged in release media, connected to the external system (Figure 1), actuated using a customisable actuation regime (MatLab®), and concentration of released Dextran determined using absorbance measurements. The actuation regime was modified until the optimal pressure, ramp, and cycle number were selected to facilitate controlled release of Dextran.