PD-1 and its ligands in tolerance and immunity
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that
regulate the balance between T cell activation, tolerance, and immunopathology. Immune
responses to foreign and self-antigens require specific and balanced responses to clear
pathogens and tumors and yet maintain tolerance. Induction and maintenance of T cell
tolerance requires PD-1, and its ligand PD-L1 on nonhematopoietic cells can limit effector T
cell responses and protect tissues from immune-mediated tissue damage. The PD-1: PD-L …
regulate the balance between T cell activation, tolerance, and immunopathology. Immune
responses to foreign and self-antigens require specific and balanced responses to clear
pathogens and tumors and yet maintain tolerance. Induction and maintenance of T cell
tolerance requires PD-1, and its ligand PD-L1 on nonhematopoietic cells can limit effector T
cell responses and protect tissues from immune-mediated tissue damage. The PD-1: PD-L …
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