… More surprisingly, an ATP binding site mutant of ILK1, with a … 1), also promotes insulin-induced
phosphorylation of Akt at … 473 phosphorylation of Akt by providing an adaptor function. …

… as a PDK2 that catalyzes the phosphorylation of Akt and p70 … COOH-terminal (C-tail) HM.
Alternatively, phosphorylation of … mTOR/rictor complex catalyzes phosphorylation of Akt at the …

… Akt 1 appears to be the predominantly expressed isoform in most tissues, … Akt kinase activity
is an attractive avenue for therapeutic intervention in a variety of human malignancies. As an …

… This results in the inhibition of the downstream mTOR complex 1 and S6K1 signaling …
system (Bayer) following tail incision. The mice were then injected intraperitoneally with 1 mU/g of …

… and a C-terminal regulatory tail (Figure 3). Two specific sites, … elegans (AKT-1 and AKT-2;
the akt-1 gene gives rise to two … a distinct protein kinase, tentatively termed PDK2 [29]. Recent …

… is more complex. This review aims to provide … ‘Is the role of PIP3 activity on PDK1 and
Akt/PKB in doubt?', we critically … of GSK3 by Akt/PKB at the N-terminal tail induces a phosphate-…

… a serine in the C-terminal tail. PDK1 has clearly been shown to … Protein kinase B (PKB), 1
also known as Akt, is a 60 kDa … is to displace PDK2 from the PKB/PKCζ/PDK2 complex. Many …

… -dependent protein kinase 1) phosphorylates Akt at a … target of rapamycin) complex 2]
phosphorylates Akt at a serine … a C-terminal regulatory tail containing the HM phosphorylation …

… ), via PDK1 and PDK2, … of Akt from the Hsp90 complex increases Akt sensitivity to PP2A-mediated
dephosphorylation and subsequent degradation. Blockade of the Akt-HSP-90 complex …

… tail (the C-terminal end), changing its internalization as well as its trafficking. The current review
aimed to explain the mechanisms of the PDK1/Akt/… is a complex process and is one of the …