PI(4,5)P2 Clustering and Its Impact on Biological Functions
Y Wen, VM Vogt, GW Feigenson - Annual Review of …, 2021 - annualreviews.org
Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4, 5-
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis
and turnover both spatially and temporally regulated, PI (4, 5) P2 recruits and interacts with
hundreds of cellular proteins to support a broad spectrum of cellular functions. Several
factors contribute to the versatile and dynamic distribution of PI (4, 5) P2 in membranes.
Physiological multivalent cations such as Ca2+ and Mg2+ can bridge between PI (4, 5) P2 …
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis
and turnover both spatially and temporally regulated, PI (4, 5) P2 recruits and interacts with
hundreds of cellular proteins to support a broad spectrum of cellular functions. Several
factors contribute to the versatile and dynamic distribution of PI (4, 5) P2 in membranes.
Physiological multivalent cations such as Ca2+ and Mg2+ can bridge between PI (4, 5) P2 …
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