… The PI3Kδ inhibitor idelalisib frequently causes colitis … PI3Kδ syndrome (APDS; also called
PASLI disease) is a newly described primary immunodeficiency caused by hyperactive PI3Kδ …

… immunodeficiency that shares clinical features with common variable immunodeficiency (…
We screened a cohort of 669 molecularly undefined primary immunodeficiency patients for …

… PI3Kδ enzyme complex and its regulation or dysregulation in the context of immunodeficiency…
patients with a large number of primary immune deficiencies, the presence of low numbers …

… of PI3Kδ, p110δ, lead to human primary immunodeficiencies. … insight into pathways regulated
by PI3Kδ in T and B cells and … We highlight critical roles of PI3Kδ in T follicular helper cells …

… expression of mutant PI3Kδ D853Gfs at a … PI3Kδ D853Gfs mutant copurified with His-tagged
p85α (Fig 1, E), but lacked kinase activity, as demonstrated by failure of recombinant PI3Kδ …

… in PTEN (terminates PI3Kδ signalling) … PI3Kδ inhibitors can be administered. In this review,
we provide an update on the clinical and laboratory features of this primary immunodeficiency…

… mutations that can cause primary immunodeficiency provides valuable insight into the role …
primary immunodeficiency patients, particularly those with hyperactivating mutations in PI3Kδ …

… corrected by addition of the PI3Kδ inhibitor IC87114. Furthermore, … Primary immune deficiency
diseases arise due to heritable … in primary immune deficiencies such as severe combined …

… E1021K) as a cause for primary immunodeficiency [3-5]. The … PI3Kδ inhibitor IC87114
reduced the increased AICD in patient cells. In addition, patients T cell blasts treated with the PI3Kδ…

… leukocyte subsets but mouse models of PI3Kδ deficiency imply wide-ranging impairments
of … This primary immunodeficiency thus highlights the central importance of regulated PI3Kδ …