… and PIP2 lipids in the studied membranes. Altogether, our results give new insight into
integrin–talin interactions with an emphasis on PIP2 and its role in integrin activation. …

… of different talin recruitment and/or activation factors to integrin … talin as a direct effector of
Rap1, which binds to the talin F0 … with PIP2–talin F1(loop)F2F3 interaction to trigger integrin …

… The phosphoinositides PIP2 and PIP3 control the binding of talin and kindlin at the surface
of GUVs. (A) Representative epifluorescence images of GUVs without PIPs (left) or with …

… PIP2 interacts with Talin-1 F2 and F3 and induces the … capable of transmitting mechanical
forces imposed on cells externally… tail of integrin β subunits, Talin-1 controls integrin activation, …

… It has been shown that PIP5KIγ is required for efficient FAK activation, providing strong
support to the notion that PIP 2 is a key mediator of the integrin-FAK signaling link ( …

… the interactions of integrin and the talin head domain using … the talinintegrin binding
interface in a set of constant force … increase the local concentration of PIP2 in the inner leaflet of …

… In contrast, the binding of talin to bilayers containing PIP2 is insensitive to the presence of …
PIP2 as an effective activator of talin. The interaction of PIP2 with talin head for activation was …

… shown to bind and activate integrin and to bind to F-actin (5, 6). Because talin binds to crucial
… Once at the membrane, phosphatidylinositol 4,5-bisphosphate (PIP2; generated by PIPKIg) …

… -4,5-bisphosphate (PIP2) plays a specific role in the talin mediated integrin activation by
promoting … of the interaction of talin with PIPKIγ and production of PIP2 at the site of adhesion. …

… It is best known for its ability to reinforce the physical link between the cytoskeleton and
the adhesion machinery by forming additional connections between talin and F-actin ( …