[PDF][PDF] Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency
K Pierzynowska, J Valverde-Piedra… - Archives of Medical …, 2018 - termedia.pl
Archives of Medical Science, 2018•termedia.pl
Results: The PLEM enhanced fat and protein digestion, and reversed growth impairment in
EPI pigs. With treatment, CFA and CNA increased by 59% and 43%(p< 0.05), respectively.
Although fat and protein absorption were lower than in the comparator, the postprandial
blood lipid profile was normal as in healthy pigs. The mucosal thickness significantly
increased by 27%, 50% and 26%, in the proximal, middle, and distal jejunum (p< 0.05) with
treatment and resembled that of healthy animals. Conclusions: Pancreatic-like enzymes of …
EPI pigs. With treatment, CFA and CNA increased by 59% and 43%(p< 0.05), respectively.
Although fat and protein absorption were lower than in the comparator, the postprandial
blood lipid profile was normal as in healthy pigs. The mucosal thickness significantly
increased by 27%, 50% and 26%, in the proximal, middle, and distal jejunum (p< 0.05) with
treatment and resembled that of healthy animals. Conclusions: Pancreatic-like enzymes of …
Results: The PLEM enhanced fat and protein digestion, and reversed growth impairment in EPI pigs. With treatment, CFA and CNA increased by 59% and 43%(p< 0.05), respectively. Although fat and protein absorption were lower than in the comparator, the postprandial blood lipid profile was normal as in healthy pigs. The mucosal thickness significantly increased by 27%, 50% and 26%, in the proximal, middle, and distal jejunum (p< 0.05) with treatment and resembled that of healthy animals.
Conclusions: Pancreatic-like enzymes of microbial origin supported somatic growth and normalized the postprandial lipid profile. As a measure of efficacy, postprandial LI, TG and NEFA are viable endpoints to be explored in human trials.
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