Pandemic paradox: early life H2N2 pandemic influenza infection enhanced susceptibility to death during the 2009 H1N1 pandemic
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid
reminder of the potentially devastating effects that a novel pandemic could exert on the
modern world. Those who have survived infections with influenza viruses in the past have
been protected from subsequent antigenically similar pandemics through adaptive immunity.
For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses
that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result …
reminder of the potentially devastating effects that a novel pandemic could exert on the
modern world. Those who have survived infections with influenza viruses in the past have
been protected from subsequent antigenically similar pandemics through adaptive immunity.
For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses
that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result …
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