Striped catfish (Pangasianodon hipophthalmus) is one of economic important fish species which has slower growth rate compared to other freshwater fish. The addition of enzymes to artificial fish feed is aimed to maximize the protein utilization for fish growth. Papain and bromelain enzymes are exogenous enzymes which can aid in the process of protein hydrolysis. This study aims to determine the effect of papain and bromelain enzyme combination toward daily growth rate (DGR) and feed utilization efficiency (FE). The research was conducted in March-June 2017 at Floating Fish Cage (FFC) of Fisheries and Ornamental Fish Conservation Centre of Cirata Reservoir-West Java, Indonesia. The materials used were 270 individuals of striped catfish with average weight of 20 g and 8-12 cm length. The method used was Completely Randomized Design (CRD) consisting of 6 treatments: A (without enzyme addition), B (5% papain), C (3.75% papain and 1.25% bromelain), D (2.5% papain and 2.5% bromelain), E (1.25% papain and 3.75% bromelain) and F (5% bromelain) with 3 replications each. Data analysis was performed by using F test analysis and continued with Duncan Multiple Range Test. The results showed that the combination of papain and bromelain enzymes can increase the rate of DGR and FUE. Treatment E gave the highest DGR and FUE values by 2.22% and 4.45% respectively.