The study investigated influence of parental relationship on the psychological wellbeing of southeastern adolescents. A descriptive survey design was adopted for the study with 4000 (2000 males and 2000 females) adolescents in senior secondary II from schools in Abia, Enugu, Imo and Anambra States of Nigeria as the sample. A questionnaire whose reliability coefficient was 0.60 was used to collect information. The result showed that: the adolescents have more emotional and social than personal problems; among others. The finding lends credence to Videon's (2005) report that parents (mothers and fathers) have a lot of influence on adolescent psychological wellbeing. It was recommended that guidance counselors should handle each adolescent problem with full knowledge of the cultural milieu and gender of clients in addition to organizing family seminars on parenting practices and parent/adolescent relationship.