Parts-prospecting for a high-efficiency thiamin thiazole biosynthesis pathway
Plants synthesize the thiazole precursor of thiamin (cThz-P) via THIAMIN4 (THI4), a suicide
enzyme that mediates one reaction cycle and must then be degraded and resynthesized. It
has been estimated that this THI4 turnover consumes 2% to 12% of the maintenance energy
budget and that installing an energy-efficient alternative pathway could substantially
increase crop yield potential. Available data point to two natural alternatives to the suicidal
THI4 pathway:(i) nonsuicidal prokaryotic THI4s that lack the active-site Cys residue on which …
enzyme that mediates one reaction cycle and must then be degraded and resynthesized. It
has been estimated that this THI4 turnover consumes 2% to 12% of the maintenance energy
budget and that installing an energy-efficient alternative pathway could substantially
increase crop yield potential. Available data point to two natural alternatives to the suicidal
THI4 pathway:(i) nonsuicidal prokaryotic THI4s that lack the active-site Cys residue on which …
Parts-prospecting for a high-efficiency thiamin thiazole biosynthesis pathway.
SJY Sun JiaYi, CL Sigler, GAW Beaudoin, J Joshi… - 2019 - cabidigitallibrary.org
Plants synthesize the thiazole precursor of thiamin (cThz-P) via THIAMIN4 (THI4), a suicide
enzyme that mediates one reaction cycle and must then be degraded and resynthesized. It
has been estimated that this THI4 turnover consumes 2% to 12% of the maintenance energy
budget and that installing an energy-efficient alternative pathway could substantially
increase crop yield potential. Available data point to two natural alternatives to the suicidal
THI4 pathway:(i) nonsuicidal prokaryotic THI4s that lack the active-site Cys residue on which …
enzyme that mediates one reaction cycle and must then be degraded and resynthesized. It
has been estimated that this THI4 turnover consumes 2% to 12% of the maintenance energy
budget and that installing an energy-efficient alternative pathway could substantially
increase crop yield potential. Available data point to two natural alternatives to the suicidal
THI4 pathway:(i) nonsuicidal prokaryotic THI4s that lack the active-site Cys residue on which …