Passive transport across bilayer lipid membranes: Overton continues to rule
A Missner, P Kügler… - Proceedings of the …, 2008 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2008•National Acad Sciences
According to Overton's rule, membrane permeability (PM) of a molecule increases with its
hydrophobicity. Experiments with a series of carboxylic acids now suggest the opposite: the
most hydrophilic acid exhibited the highest PM (1). The experiments, however, do not justify
this conclusion for the following reasons:(i) The reported membrane resistance (RM 1/PM
1/2.2 10 3 cm/s) is much lower than that of near-membrane unstirred layers (UL)(RUL
1/PUL). As every resistance adds to the total resistance (R 1/P)(2), we arrive at
hydrophobicity. Experiments with a series of carboxylic acids now suggest the opposite: the
most hydrophilic acid exhibited the highest PM (1). The experiments, however, do not justify
this conclusion for the following reasons:(i) The reported membrane resistance (RM 1/PM
1/2.2 10 3 cm/s) is much lower than that of near-membrane unstirred layers (UL)(RUL
1/PUL). As every resistance adds to the total resistance (R 1/P)(2), we arrive at
According to Overton’s rule, membrane permeability (PM) of a molecule increases with its hydrophobicity. Experiments with a series of carboxylic acids now suggest the opposite: the most hydrophilic acid exhibited the highest PM (1). The experiments, however, do not justify this conclusion for the following reasons:(i) The reported membrane resistance (RM 1/PM 1/2.2 10 3 cm/s) is much lower than that of near-membrane unstirred layers (UL)(RUL 1/PUL). As every resistance adds to the total resistance (R 1/P)(2), we arrive at
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