Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute
M Wassef, BT Baxter, RL Chisholm… - Journal of vascular …, 2001 - jvascsurg.org
MMP-9 and aortic aneurysms—developing a model. The long-term goal of the research
group at Northwestern University is to understand the role of MMP-9 in the pathogenesis of
AAAs. Preliminary studies have demonstrated a significant correlation between aneurysm
size and aortic wall expression of MMP-9 messenger RNA (mRNA), and patients with AAAs
also exhibit elevated plasma levels of MMP-9. On the basis of these studies, the
investigators proposed that the mechanisms of arterial wall repair are abnormal in patients …
group at Northwestern University is to understand the role of MMP-9 in the pathogenesis of
AAAs. Preliminary studies have demonstrated a significant correlation between aneurysm
size and aortic wall expression of MMP-9 messenger RNA (mRNA), and patients with AAAs
also exhibit elevated plasma levels of MMP-9. On the basis of these studies, the
investigators proposed that the mechanisms of arterial wall repair are abnormal in patients …
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