Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat
M Kawakami, T Tamaki, JN Weinstein, H Hashizume… - Spine, 1996 - journals.lww.com
M Kawakami, T Tamaki, JN Weinstein, H Hashizume, H Nishi, ST Meller
Spine, 1996•journals.lww.com… In the present study, the applications of retroperitoneal fat tissues and intervertebral disc
materials into the lumbar epidural space were not autografts, but were allografts resected
from another Sprague-Dawley rat. The reasons for using allografts in this study are 1) it is
necessary to prevent lumbar kyphotic deformity after resection of the lumbar intervertebral
discs, and 2) it is difficult to harvest sufficient intervertebral disc tissue from three levels in
the lumbar spine of the same experimental rat. Rats in the fat group showed evidence of …
materials into the lumbar epidural space were not autografts, but were allografts resected
from another Sprague-Dawley rat. The reasons for using allografts in this study are 1) it is
necessary to prevent lumbar kyphotic deformity after resection of the lumbar intervertebral
discs, and 2) it is difficult to harvest sufficient intervertebral disc tissue from three levels in
the lumbar spine of the same experimental rat. Rats in the fat group showed evidence of …
Abstract
Study Design
This study was designed to evaluate whether allografts of intervertebral disc materials produce hyperalgesia in the rat and whether an immune response, pH, or chemicals correlate with the induced hyperalgesia.
Objective
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