[HTML][HTML] Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
T Fazolo, K Lima, JC Fontoura, PO de Souza… - Nature …, 2021 - nature.com
COVID-19 manifests as a milder disease in children than adults, but the underlying
mechanisms are not fully characterized. Here we assess the difference in cellular or humoral
immune responses of pediatric and adult COVID-19 patients to see if these factors contribute
to the severity dichotomy. Children's non-specific immune profile is dominated by naive
lymphocytes and HLA-DRhighCX3CR1low dendritic cells; meanwhile, children show strong
specific antibody and T cell responses for viral structural proteins, with their T cell responses …
mechanisms are not fully characterized. Here we assess the difference in cellular or humoral
immune responses of pediatric and adult COVID-19 patients to see if these factors contribute
to the severity dichotomy. Children's non-specific immune profile is dominated by naive
lymphocytes and HLA-DRhighCX3CR1low dendritic cells; meanwhile, children show strong
specific antibody and T cell responses for viral structural proteins, with their T cell responses …
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