Pediatric atopic dermatitis: a review of the medical management
A Carbone, A Siu, R Patel - Annals of Pharmacotherapy, 2010 - journals.sagepub.com
A Carbone, A Siu, R Patel
Annals of Pharmacotherapy, 2010•journals.sagepub.comObjective: To evaluate the available treatment options for pediatric atopic dermatitis, Data
Sources: A literature review was performed in MEDLINE (1950-February 2010) using the
key word atopic dermatitis. The references identified were evaluated in comparative
treatment. The references included in this review were limited to studies conducted in
children less than 18 years of age and written in the English language. Study Selection and
Data Extraction: All of the literature retrieved that was published within the last 5 years (2005 …
Sources: A literature review was performed in MEDLINE (1950-February 2010) using the
key word atopic dermatitis. The references identified were evaluated in comparative
treatment. The references included in this review were limited to studies conducted in
children less than 18 years of age and written in the English language. Study Selection and
Data Extraction: All of the literature retrieved that was published within the last 5 years (2005 …
Objective
To evaluate the available treatment options for pediatric atopic dermatitis,
Data Sources
A literature review was performed in MEDLINE (1950-February 2010) using the key word atopic dermatitis. The references identified were evaluated in comparative treatment. The references included in this review were limited to studies conducted in children less than 18 years of age and written in the English language.
Study Selection and Data Extraction
All of the literature retrieved that was published within the last 5 years (2005-2010) was included in this review. Other pertinent articles published prior to 2005 were also included.
Data Synthesis
Atopic dermatitis is a chronic inflammatory skin disorder that usually begins during infancy. Potential causes include irritants such as soap and detergents, food allergens, contact allergens, and skin infections. Emollients, moisturizing agents that inhibit water loss and provide a protective coating, are recommended in all patients with atopic dermatitis. Additionally, emollients may reduce the need to use topical corticosteroids. Patients receiving desanide 0.05% plus an emollient achieved significant reductions in severity scores compared to those receiving desonide 0.05% as monotherapy (80% vs 70%; p < 0.01). Topical calcineurin inhibitors are not recommended as first-line therapy in pediatric patients with atopic dermatitis; however, their use in children above 2 years of age who fail to respond to topical corticosteroids may be considered.
Conclusions
Emollients are recommended in pediatric patients with a diagnosis of atopic dermatitis regardless of symptoms. Topical corticosteroids reduce the inflammation and pruritus associated with atopic dermatitis and are available in several formulations and strengths. Calcineurin inhibitors may be an alternative in children older than 2 years of age who do not respond to topical corticosteroids,
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