[PDF][PDF] Pedunculopontine nucleus stimulation influences REM sleep in Parkinson's disease

A Romigi, F Placidi, A Peppe, M Pierantozzi… - European Journal of …, 2008 - academia.edu
A Romigi, F Placidi, A Peppe, M Pierantozzi, F Izzi, L Brusa, S Galati, V Moschella…
European Journal of Neurology, 2008academia.edu
… Sirs, The pedunculopontine nucleus (PPN) is recognized as a critical modulator of sleep-wakefulness
transitions. We proposed recently the combined deep brain stimulation (DBS) of PPN plus
the subthalamic nucleus (STN) as a new option for severe Parkinson’s disease (PD)
patients [1]. In one of those patients (UM male, 46 years), we monitored polysomnographic (PSG)
macrostructure alterations since the late 1990s. Hence, changes related to the …
Correspondence: Alessandro Stefani, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy (tel.:+ 39620903119; fax:+ 39620903118; e-mail: stefani@ uniroma2. it).
academia.edu
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