Hypertension is considered as one of the highest death-caused disease worldwide.
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) most frequently occurred in elderly and those who
had comorbid diseases, one of them is hypertension. The first line drugs that are usually
used in hypertension are angiotensin converting enzyme inhibitors (ACEIs) and angiotensin
receptor blockers (ARBs). It is assumed that these drugs coud influence the progress of …

Background: COVID-19 has a high prevalence in patients with underlying comorbidity, such
as cardiovascular disease. Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin
receptor blocker (ARB) therapy in COVID-19 patients with cardiovascular disease
comorbidity gives rise to a controversy for ACEI and ARB could upregulate angiotensin-
converting enzyme 2 (ACE2) expression in a previous study in animals. ACE2 is considered
a receptor for SARS-CoV-2, suggesting that ACEI and ARB consumption would worsen the …