Summary Background The Synergy between PCI with Taxus and Cardiac Surgery
(SYNTAX) trial was a non-inferiority trial that compared percutaneous coronary intervention
(PCI) using first-generation paclitaxel-eluting stents with coronary artery bypass grafting
(CABG) in patients with de-novo three-vessel and left main coronary artery disease, and
reported results up to 5 years. We now report 10-year all-cause death results. Methods The
SYNTAX Extended Survival (SYNTAXES) study is an investigator-driven extension of follow …

Importance In patients with left main coronary artery (LMCA) stenosis, coronary artery
bypass grafting (CABG) has been the standard therapy for several decades. However, some
studies suggest that percutaneous coronary intervention (PCI) with drug-eluting stents may
be an acceptable alternative. Objective To compare the long-term safety of PCI with drug-
eluting stent vs CABG in patients with LMCA stenosis. Data Sources PubMed, Scopus,
EMBASE, Web of Knowledge, and ScienceDirect databases were searched from December …