Phage Cocktails with Daptomycin and Ampicillin Eradicates Biofilm-Embedded Multidrug-Resistant Enterococcus faecium with Preserved Phage Susceptibility

AJK Coyne, K Stamper, R Kebriaei, DJ Holger… - Antibiotics, 2022 - mdpi.com
… that in instances of biofilm-embedded MDR E. faecium, the addition of select bacteriophage
cocktails to DAP + AMP may be a promising option to eradicate biofilm-mediated infections …

Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR Enterococcus faecium

K Lev, AJ Kunz Coyne, R Kebriaei, T Morrisette… - Antibiotics, 2022 - mdpi.com
… faecium strains, daptomycin (DAP)-resistant R497 and DAP-… , combinations with phage-DAP-ampicillin
(AMP), phage-DAP… In summary, we show that in instances of multidrug-resistant

Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms

AJ Kunz Coyne, K Stamper, C Bleick… - Microbiology …, 2024 - Am Soc Microbiol
… caused by multidrug-resistant S. aureus clinical isolates (11… 2-phage or 3-phage cocktail,
and (A3, B3) daptomycin plus … exposures and phage cocktails on biofilm-embedded D712 and …

Antimicrobial strategies effective against infectious bacterial biofilms

M Simoes - Current medicinal chemistry, 2011 - ingentaconnect.com
… was synergistic against biofilm-embedded MRSA [30]. In … The proposed mode of action
indicates that daptomycin binds to cell … New strategies should ideally eradicate multidrugresistant

Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections

S De Soir, H Parée, NHN Kamarudin… - Microbiology …, 2024 - Am Soc Microbiol
phages or the phage cocktail did not cause any significant reduction in biomass. However,
when phage-… Combinations of ciprofloxacin with individual phages and the phage cocktail

Phage-antibiotic cocktail rescues daptomycin and phage susceptibility against daptomycin-nonsusceptible Enterococcus faecium in a simulated endocardial …

AJ Kunz Coyne, K Stamper, A El Ghali… - Microbiology …, 2023 - Am Soc Microbiol
… viruses are used to treat bacterial infections, has been proposed as a salvage therapy,
especially in the context of high inoculum-infections and those caused by multidrug-resistant

Bacteriophage and antibiotic combination therapy for recurrent Enterococcus faecium bacteremia

ME Stellfox, C Fernandes, RK Shields, G Haidar… - Mbio, 2024 - Am Soc Microbiol
… observed enhanced bacterial growth suppression when the phage cocktail was used in
combination with daptomycin as compared to either phage or daptomycin alone (Fig. S3D). …

Phage-antibiotic synergy against daptomycin-nonsusceptible MRSA in an ex vivo simulated endocardial pharmacokinetic/pharmacodynamic model

AJ Kunz Coyne, C Bleick, K Stamper… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
phages when the model regimen consisted of phage cocktailphage following regimens
that included DAP or DAP + CPT, suggesting that these PACs reduced the frequency of phage

Combining bacteriophages with other antibacterial agents to combat bacteria

P Knezevic, V Aleksic Sabo - Phage Therapy: A Practical Approach, 2019 - Springer
… both against planktonic and biofilm embedded bacterial cells and … of the approaches to
combat multidrug-resistant bacteria is to … For some antimicrobials (ciprofloxacin, daptomycin, and …

Ecology and evolutionary biology of hindering phage therapy: The phage tolerance vs. phage resistance of bacterial biofilms

ST Abedon - Antibiotics, 2023 - mdpi.com
… Considered in this review especially are general principles of phage tolerance and phage
resistance… 2TG against a pathogenic multidrug-resistant Aeromonas hydrophila in Nile tilapia (…