过去一年中添加的文章,按日期排序

Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis

WJ Wiersinga, MA van Agtmael - JAMA, 2024 - jamanetwork.com
4 天前 - … But does a better pharmacokinetic target mean a better clinical outcome? Numerous
… of cefepime in critically ill patients.No differences in clinical outcomes (mean ICU stay, …

Therapeutic Drug Monitoring and Pharmacokinetics-Based Individualization of Drug Therapy

GB Karvaly, B Vásárhelyi - Pharmaceutics, 2024 - mdpi.com
4 天前 - … The authors of contribution (7) investigated its population pharmacokinetics in
critically ill adults for the first time. They revealed that serum albumin concentration and chronic …

Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a …

M Gatti, F Pea - Frontiers in Antibiotics - frontiersin.org
12 天前 - … most frequent antimicrobials used in critical OLT recipients… issues potentially
affecting the pharmacokinetics of beta-… of attaining adequate pharmacokinetic/pharmacodynamic …

[引用][C] Personalising antimicrobial therapy in critically ill patients using Bayesian dosing software

M Chai - 2024 - espace.library.uq.edu.au
16 天前 - … group is challenging as the physiological changes seen with critical illness and …
Many critically patients fail to achieve antimicrobial pharmacokinetic-pharmacodynamic (PK-PD…

[HTML][HTML] Prevention of ventilator-associated pneumonia with inhaled antibiotics

S Ehrmann, J Li - World Journal of Emergency Medicine, 2024 - ncbi.nlm.nih.gov
17 天前 - pharmacokinetics. This interest has been particularly pronounced in the context of
critically ill patientsantibiotics for intubated patients. Recent high-level evidence has shown a …

[PDF][PDF] Comparative Efficacy of Twice and Thrice Daily Colistin Administration in Critically Ill Patients Battling Multi-Drug Resistant Gram-Negative Infections: An …

MV Hydross, SA Samad, MB Savitri, A Datt - J Med Microbiol, 2024 - jommid.pasteur.ac.ir
19 天前 - … , with critically ill patients posing unique challenges … ) of colistin in 151 critically ill
patients with multidrug-resistant Gram… pharmacokinetics are not significantly affected by patient

… drug monitoring of 10 drug compounds commonly used for antimicrobial therapy in plasma and serum of critically ill patients: Method optimization, validation, cross …

SK Neef, AD Hinderer, W Arbash, M Kinzig, F Sörgel… - Clinica Chimica …, 2024 - Elsevier
51 天前 - … Intensive care antibiotic treatment faces challenges due to substantial pharmacokinetic
differences in critically ill patients. Individualized antibiotic dosing guided by therapeutic …

… of Piperacillin-Tazobactam vs. Meropenem on the Trend over Time of SOFA Score and Inflammatory Biomarkers in Critically Ill Patients Receiving Continuous Infusion …

M Gatti, M Rinaldi, T Tonetti, A Siniscalchi, P Viale… - Antibiotics, 2024 - mdpi.com
83 天前 - … combinations in critically ill septic patients still remains a debated issue. We aimed
to assess the comparative impact of an optimized pharmacokinetic/pharmacodynamic (PK/…

Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges

M Colaneri, C Genovese, P Valsecchi, M Calia… - … and Pharmacokinetics, 2024 - Springer
128 天前 - … be deemed at risk of likely altered pharmacokinetic/pharmacodynamic values.
Moreover, despite many critically ill patients developing acute kidney injury, augmented renal …

Pharmacokinetic parameters of CAZ–AVI in the normal lung and in models of pneumonia: lessons for treatment optimization in critical care

S Gul, R Gallo, L Bertolino, F Patauner… - Journal of …, 2024 - Taylor & Francis
145 天前 - … In this narrative review, we summarize data on pharmacokinetic (PK) parameters
for CAZ-AVI in both animal and human models of pneumonia, as well as in healthy individuals…