Pharmacokinetic study of xylazine in a zebrafish water tank, a human-like surrogate, by liquid chromatography Q-Orbitrap mass spectrometry
RR Matos, MEP Martucci, CS de Anselmo… - Forensic …, 2020 - Springer
Purpose This study aims to investigate a zebrafish (Danio Rerio) water tank (ZWT) as an
alternative model for the study of the metabolism of xylazine. Methods The ZWT approach for
the study of metabolism consisted of two aquariums, where 18 fish and xylazine were added
into the first tank. The second one, with 18 fish without drug, served as a negative control.
The samples were submitted to a comprehensive analytical method developed for doping
control purposes by liquid chromatography (LC) coupled with high-resolution mass …
alternative model for the study of the metabolism of xylazine. Methods The ZWT approach for
the study of metabolism consisted of two aquariums, where 18 fish and xylazine were added
into the first tank. The second one, with 18 fish without drug, served as a negative control.
The samples were submitted to a comprehensive analytical method developed for doping
control purposes by liquid chromatography (LC) coupled with high-resolution mass …
[引用][C] Pharmacokinetic study of xylazine in a zebrafsh water tank, a human‑like surrogate, by liquid chromatography Q‑Orbitrap mass spectrometry.
RR Mato, MEP Martucci, CS Anselmo, FR Aquino Neto… - 2020
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